G-CSF+/- Plerixafor Is Superior To Cyclophosphamide+G/Gm-CSF For Autologous Hematopoietic Stem Cells (AHSC) Mobilization
نویسندگان
چکیده
منابع مشابه
The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone.
Hematopoietic progenitor cells (HPCs) traffic to and are retained in the marrow through the trophic effects of the chemokine stromal cell-derived factor-1alpha (SDF-1alpha) binding to its receptor, CXC chemokine receptor 4 (CXCR4). AMD3100 reversibly inhibits SDF-1alpha/CXCR4 binding, and AMD3100 administration mobilizes CD34(+) cells into the circulation. We therefore tested the hypotheses tha...
متن کاملPlerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma.
This phase 3, multicenter, randomized (1:1), double-blind, placebo-controlled study evaluated the safety and efficacy of plerixafor with granulocyte colony-stimulating factor (G-CSF) in mobilizing hematopoietic stem cells in patients with multiple myeloma. Patients received G-CSF (10 microg/kg) subcutaneously daily for up to 8 days. Beginning on day 4 and continuing daily for up to 4 days, pati...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma
1Washington University, St Louis, MO; 2Abramson Cancer Center of the University of Pennsylvania, Philadelphia; 3City of Hope Comprehensive Cancer Center, Duarte, CA; 4Mayo Clinic, Rochester, MN; 5Loyola University, Chicago, IL; 6Emory University, Atlanta, GA; 7Oregon Health & Science University, Portland; 8M. D. Anderson Cancer Center, Houston, TX; 9Universitätsklinikum Heidelberg, Heidelberg, ...
متن کاملBiosimilar G-CSF Based Mobilization of Peripheral Blood Hematopoietic Stem Cells for Autologous and Allogeneic Stem Cell Transplantation
The use of granulocyte colony stimulating factor (G-CSF) biosimilars for peripheral blood hematopoietic stem cell (PBSC) mobilization has stimulated an ongoing debate regarding their efficacy and safety. However, the use of biosimilar G-CSF was approved by the European Medicines Agency (EMA) for all the registered indications of the originator G-CSF (Neupogen (®) ) including mobilization of ste...
متن کاملExpression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF.
The mechanisms that regulate hematopoietic progenitor cell (HPC) mobilization from the bone marrow to blood have not yet been defined. HPC mobilization by granulocyte colony-stimulating factor (G-CSF), cyclophosphamide (CY), or interleukin-8 but not flt-3 ligand is markedly impaired in G-CSF receptor-deficient (G-CSFR-deficient) mice. G-CSFR is expressed on mature hematopoietic cells, HPCs, and...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2010
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2009.12.155